We proud to have played a major role in a multi year collaboration to produce the most comprehensive collection of cannabis genomic data - and were published in Nature! Not only is nature one of the most respected scientific journals in existence, the information is completely available in the public sphere!
Discover the untamed genetic diversity of Cannabis sativa like never before. In this groundbreaking study we helped unveil the most extensive cannabis pangenome to date—an extraordinary assembly of 193 genomes (181 new and 12 existing) spanning both male (XY) and female (XX) plants . This comprehensive genomic atlas reveals a striking mosaic: immense structural and genetic variation across most of the genome, contrasted by highly conserved clusters of domesticated cannabinoid synthase genes responsible for THC and CBD production.
Delving into the complexities of sex determination, the team mapped variable boundaries in the ancient X and Y chromosomes and pinpointed male-biased expression in key flowering regulators.
Additionally, they uncovered specialized gene variants linked to rare cannabinoids like THCV and CBDV, opening new avenues for tailored breeding.
By charting uncharted genomic territory and proposing a history of hybridization and population structure, this pioneering research highlights the untapped potential of wild cannabis germplasm and paves the way for innovations in breeding, medicine, fiber production, and industrial biotechnology.
Domesticated cannabinoid synthases amid a wild mosaic cannabis pangenome
